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They put in a negative inotropic result probably mediated through nitric oxide supplements (Zero). Studies show that IL-6 inhibited myocardial contractility through production of NO, advising as a result that this manufacture of IL-6 might be a pathogenic aspect in the stunned myocardium [65]. Moreover, IL-1 along with TNF-a stimulate down-regulation of adrenergic receptiveness within the myocard

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